compounds from the diversity-oriented synthesis library Search Results


93,672 cpds from diversity oriented synthesis (dos) library  (Broad Institute Inc)
90
Broad Institute Inc 93,672 cpds from diversity oriented synthesis (dos) library
RAD52 inhibitors.
93,672 Cpds From Diversity Oriented Synthesis (Dos) Library, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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93,672 cpds from diversity oriented synthesis (dos) library - by Bioz Stars, 2026-07
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RAD52 inhibitors.

Journal: Cancers

Article Title: Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

doi: 10.3390/cancers15061817

Figure Lengend Snippet: RAD52 inhibitors.

Article Snippet: D-I03 , DSB repair (ssDNA: 93,672 cpds from Diversity Oriented Synthesis (DOS) library and 279,231 cpds from Molecular Libraries Probe Center Network (MPLCN) - Broad Institute) , DSB repair (ssDNA annealing: IC 50 = 5 μM, D-loop: IC 50 = 8 μM); RAD52 binding (SPR: K d = 25.8 μM) , BRCA1/2± cell survival (viability and clonogenic: IC 50 = 14.5 μM for BRCA1/2− cells over BRCA1/2+ and combination with PARPi); foci (2.5 μM ≈ 2.0-fold reduction of RAD52 and not of RAD51); DSB repair (SSA, 30 μM ≈ 3.4-fold reduction and selective over HR) , PARPi (talazoparib)+D-I03 (50 mg/kg/day) synergic against BRCA1-deficient solid tumor growth in nude mice , A. V. Mazin [ , ] .

Techniques: In Vitro, In Vivo, Flow Cytometry, Binding Assay, Western Blot, Software, Single Cell Gel Electrophoresis, Pull Down Assay, Disruption, Inhibition, shRNA